Reference & control plasmas
| Order number |
Description |
Quantity |
Delivery time |
CE |
| TC 5450210 |
TECHNOZYM® vWF:Ag Calibrator Set |
5x0.5 ml |
7-10 days |
x |
TECHNOZYM® vWF:Ag Calibrator Set
The von Willebrand Factor (vWF) is a large, multifunctional glycoprotein, occupying a key
position in primary haemostasis. It has a multiple structure with several functions:
· It is the carrier protein for Factor VIII in plasma; it forms a complex
and thus protects Factor VIII from early proteolytic decomposition.
· It acts as a mediator for platelet aggregation by attaching itself to platelet membrane
receptors (GP Ib and GP lIb/IIIa) following previous platelet activation.
· It plays a part in primary haemostasis by acting as a mediator between adhesioned platelets
and the subendothelium (lesioned vascular wall).
The von Willebrand Syndrome (vWS) is the most frequently occurring hemorrhagic disease; it
may be hereditary as well as acquired, caused by quantitative or qualitative defects of the
vWF. Determining the vWF antigen is an essential part of the diagnosis.
The vWF: Ag ELISA allows a differential diagnosis between hemophilia A and vWS and
additionnal diagnostics in case of hepatic and vascular diseases.
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