| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| GP LACD-10 | LA-Confirm | 10x2 ml | 10 days | x |
LA-ConfirmLA Screen and LA Confirm are simplified DRVVT reagents for detection of Lupus Anticoagulants (LA) in one-stage clotting tests. LAs are autoantibodies against negatively charged phospholipids or complexes of phospholipids with either beta-2-glycoprotein 1 or clotting factors such as prothrombin. They occur in various clinical conditions, especially autoimmune diseases and are now considered to be a significant risk factor in patients with otherwise unexplained thrombosis and are often present in women who have recurrent foetal loss. LA have traditionally been detected using phospholipid responsive clotting tests, such as the activated partial thromboplastin time (APTT), kaolin clotting time (KCT) and DRVVT where they have an anticoagulant effect. The DRVV time first became popular following the publication by Thiagarajan et al. in 1986. Gradipore has simplified and standardized this method. According to Petri et al, thrombosis in SLE patients is more closely linked with LA detectable by DRVVT than with anticardiolipin antibodies detected by enzyme linked immunosorbent assays (ELISA). This observation was recently extended by Galli and Bevers who showed that the LA subtype with most effect on DRVVT tests is beta-2-glycoprotein 1 dependent and different to the prothrombin-requiring LA subtype having more prolonging effect on KCT tests. |
| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| GP LAHP-05 | Gradiplasma LA High | 10x0.5ml | 10-15 days | x |
| GP LALP-1 | Gradiplasma LA Low | 10x1ml | x | |
| PB CCLP-10 | Lupus Positive Multi Donor Plasma | 25x1 ml | 7-10 days | x |
